Mathew P Leese Selected Research

2- methoxyestradiol- 3,17- bis- O,O- sulfamate

9/2008	2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique.
2/2003	Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate.

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Mathew P Leese Research Topics

Disease

14	Neoplasms (Cancer) 10/2015 - 02/2003
10	Breast Neoplasms (Breast Cancer) 02/2014 - 02/2003
3	Prostatic Neoplasms (Prostate Cancer) 02/2014 - 09/2007
1	Ovarian Neoplasms (Ovarian Cancer) 01/2021
1	Endometriosis 01/2021
1	Neurofibrosarcoma (MPNST) 10/2015
1	Hypoxia (Hypoxemia) 10/2015
1	Multiple Myeloma 01/2014

Drug/Important Bio-Agent (IBA)

7	2- methoxyestradiol- 3,17- O,O- bis(sulfamate)IBA 10/2015 - 01/2006
6	2-MethoxyestradiolIBA 10/2015 - 02/2003
5	sulfamic acid (ammonium sulfamate)IBA 02/2014 - 02/2005
5	Steryl-Sulfatase (Steroid Sulfatase)IBA 04/2010 - 02/2003
4	Hormones (Hormone)IBA 10/2015 - 02/2005
3	Pharmaceutical PreparationsIBA 02/2014 - 02/2003
2	Estrogens (Estrogen)FDA Link 01/2021 - 02/2005
2	Estrone FDA Link 01/2021 - 02/2005
2	2- methoxyestradiol- 3,17- bis- O,O- sulfamateIBA 09/2008 - 02/2003
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2021
1	EnzymesIBA 01/2021
1	Progesterone FDA LinkGeneric 10/2015
1	2-ethyloestradiol-bis-sulfamateIBA 10/2015
1	Proteins (Proteins, Gene)FDA Link 10/2015
1	SteroidsIBA 04/2014
1	1,2,3,4-tetrahydroisoquinolineIBA 02/2014
1	7- methoxy- 2- (3- methoxybenzyl)- 6- sulfamoyloxy- 1,2,3,4- tetrahydroisoquinolineIBA 02/2014
1	EstersIBA 04/2010
1	SurvivinIBA 10/2009
1	2- methoxy- 3- O- sulfamoyl- 17- cyanomethylestra- 1,3,5(10)- trieneIBA 10/2009
1	Caspase 3 (Caspase-3)IBA 10/2009
1	Angiogenesis InhibitorsIBA 09/2008
1	2-ethylestradiol sulfamateIBA 09/2008
1	2- methoxyoestra- 1,3,5(10),16- tetraene- 3- carboxamideIBA 05/2008
1	Antineoplastic Agents (Antineoplastics)IBA 03/2008
1	taxaneIBA 01/2008
1	Docetaxel (Taxotere)FDA Link 01/2008
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2008
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 09/2007
1	Oxidoreductases (Dehydrogenase)IBA 01/2006
1	Estrogen Receptor alphaIBA 10/2005
1	2-methoxyestroneIBA 04/2004
1	2-methoxyestriolIBA 02/2003

Therapy/Procedure

2	Therapeutics 10/2015 - 02/2005
1	Withholding Treatment 09/2007